Ergonomics are mostly favorable thanks to compact layouts and adjustable feet, though taller designs or form-factor changes can require some adaptation.
Ergonomics are mixed but still favorable overall: one reviewer reported no cramping or adjustment period, while another wanted more angle flexibility and a palm rest.
Ergonomics are good in some respects thanks to the wrist rest and comfortable key shapes, but the added side and left macro controls can interfere with hand placement until you adapt.